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Drug Discovery In India And China - Gaining Momentum With Increasing Pressure On Cost Cutting
Drug Discovery In India and China - Gaining Momentum with Increasing Pressure on Cost Cutting
The report provides key data, information and analysis of the major trends and issues affecting the Drug Discovery market in India and China. The report provides a comprehensive insight into the drug discovery process and the key services that form a part of drug discovery process. The report also provides a detailed analysis Indian and Chinese drug market in terms of its size, share in the global drug discovery market, major service offering of the companies in India and China along with the major therapeutic areas of focus under those services. The report also talks about the factors that are driving the drug discovery market in India and China. The report delves into the key regulations, especially with respect to intellectual property rights protection in the two countries and how the regulations have benefited the drug discovery companies in these two nations. It also provides an insight into the government support initiatives in these countries to encourage the drug discovery research. The report also analyses key partnerships between the western pharma and the local companies in the two countries and the key trends emerging out of such partnerships. At the end, the report looks into the major challenges in the future that can restrict the growth of the drug discovery market in India and China. ( http://www.bharatbook.com/detail.asp?id=130313&rt=Drug-Discovery-in-India-and-China-Gaining-Momentum-with-Increasing-Pressure-on-Cost-Cutting.html )
Rising Financial and Regulatory Pressures on Western Pharma will Continue to Drive the Drug Discovery Research Market Growth in India and China
The pharmaceutical industries in the US and Europe are facing severe financial constraints which are expected to worsen in the years ahead. The pharma companies are under increasing pressure to reduce expenditure due to, the increasing cost of introducing a NME (New Molecular Entities) (more than $3 billion in 2008), tightening FDA regulatory issues, blockbuster drugs worth more than $100 billion set to expire by 2014 and drying pipelines These pressures are expected to drive the companies towards low-cost countries such as India and China to perform their R&D activities, one of their major expenses.
Over the last decade, India and China have developed significant capabilities in drug discovery research along with considerable capabilities in phase I & II clinical trials. Both countries are able to provide significant cost savings in the range of 60–70% for discovery research and clinical trials. With discovery research occupying close to one-third of the R&D expenditure for the Western pharmaceutical industry, outsourcing to low-cost countries is logical.
Inflammatory Diseases, Metabolic Disorders and Oncology are the Three Major Therapeutic Areas of Drug Discovery Research in India and China
While the Indian and Chinese drug discovery companies have developed major service capabilities, many of the companies have also defined their therapeutic research focus. Analysis of 12 Indian and 10 Chinese companies research portfolios reveal that inflammatory diseases (18 companies), metabolic disorders (18) and cancer (16) are the top three therapeutic areas Other major therapy areas include anti-infectives and CNS (Central Nervous System). Major inflammatory disease research includes; COPD (- Chronic Obstructive Pulmonary Disease), RA (Rheumatoid Arthritis), psoriasis, osteoarthritis, ulcerative colitis and atherosclerosis.
However, at the country level the therapeutic focus is found to be different. Indian companies have concentrated their efforts on metabolic disorders; primarily diabetes, obesity and dyslipidemia. Chinese companies have focused on oncology; primarily leukemia, cervical cancer, breast cancer and prostrate cancer.
Deals Landscape is Equally Driven by Mid-Size Pharma and Big Pharma with Oncology and Metabolic Disorders as Key Therapy Area of Focus
With improvements in the capabilities of Indian and Chinese companies, the intensity of discovery research collaborations with Western pharmaceutical companies has increased.. The deals market has been equally driven by big pharma as well as mid-size pharma. Over the past year, 41 major deals have taken place in India and China, of which 20 deals involved mid-size companies while 19 involved big pharma; mainly Merck, AstraZeneca, Johnson & Johnson and Pfizer. Two of the deals were with universities. However, the increasing interest of the mid-size pharmaceutical companies suggests the rising interest of such companies to exploit the cost and quality capabilities of India and China.
Many of these deals were focused on services rather than a therapeutic area. However, among those that had a therapeutic focus; oncology, metabolic disorders, infectious diseases and inflammatory diseases were the major therapies targeted.
Funding Problems and Talent Shortage Will Be the Two Biggest Challenges in Future for the Drug Discovery Players in India and China
While the drug discovery market in India and China is growing rapidly, its future growth faces two major challenges; funding problems, especially for the private companies, and significant talent shortages in biology and chemistry services. While China has considerable government support, a large part of the money goes to government funded research institutions and universities. In India, the government has adopted PPP model as a tool to encourage pharmaceutical innovation but the major beneficiaries include CSIR (Council of Scientific and Industrial Research) affiliated institutes and small pharmaceutical companies. Venture capitalists, in both the countries, are largely risk-averse to invest in early stage R&D activities.
Besides funding problems, the lack of a sufficient talent pool with the specialized skills, experience and employability will create further problems for the drug discovery companies in both the countries.
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Why you Should Avoid Hair Care Products With Silicones and Sulfates
Several companies that produce hair care products chock of full of sulfates, detergents, parabens and silicones are continual butting heads with all natural hair care products that lack these ingredients. To make matters worse, heavily funded marketing departments for many beauty conglomerates, publish “articles” or “journals” which refute the chemical side effects of their product ingredients. Yet, the truth of the matter seems evident. Just as with food, the less refined, chemically created your product, the better it will be for your hair.
So why the outcry from companies that use these ingredients? The battle is over the word “better.” If you want a hair care product that makes your hair feel “better,” meaning softer or shinier instantaneously, but has some minor to major side effects, buy products from anyone. Yet, if you want long-lasting healthy hair that has to be built over time and produce some instant rewards, go all natural.
If you still are undecided, here is a synopsis of pros and cons of the heavyweight contenders in the hair care ingredient battles.
Silicones:
Why are silicones bad for your hair? Silicones are chemical substances that actually coat the hair, forming a shiny layer which makes the hair appear healthier and shinier. They are often found in shine sprays and hair rinses and dyes. Some silicones are water soluble, and others are not. For those that are not, they have the potential to create excessive build up on the hair, resulting in dry hair unable to receive moisture due to the presence of the layer of film. Yet, because your hair appears shinier and softer, most users of silicones are pleased with their hair until they learn it is actually damaged from all the dryness. This especially occurs with the use of hair dyes. Thus, silicones are an illusion and actually do more harm than good, depending on whether you prefer instant, false gratification or healthy hair. Keep in mind, however, that some people do love silicones and experience success with them by using them.
Sulfates:
Sodium laureth sulfate, or sodium lauryl ether sulfate (SLES), is a detergent and surfactant found in many personal care products (soaps, shampoos, toothpaste etc.). It is an inexpensive and very effective foamer. These substances provide a foaming quality to the product, allowing for better distribution of the product while washing hair or skin and while brushing teeth. While SLS is a known irritant, some evidence and research suggest that SLES can also cause irritation after extended exposure. Products containing these substances can affect those prone to eczema and other irritants. When rinsed off, the product will have cleaned the area but will have taken moisture from the top layers of skin. In people with sensitive skin (prone to dermatitis, acne, eczema, psoriasis and chemical sensitivity), the drying property of these type of detergents can cause flare-ups of skin conditions or may worsen existing conditions. The Cosmetic, Toiletry, and Fragrance Association (CTFA) and the American Cancer Society stated that the common belief that SLES is a carcinogen is an urban legend. However, the Environmental Working Group has claimed in their Skin Deep Report that SLES may possibly be contaminated with 1,4-dioxane.SLES and SLS have been known to become contaminated with 1,4-dioxane.The U.S. Environmental Protection Agency considers 1,4-dioxane to be a probable carcinogen. While the U.S. Food and Drug Administration encourages manufacturers to remove this contaminant, it is not currently required by federal law.
Many companies have “eliminated” sodium laurel sulfate in their products by claiming to use milder sulfate detergents, but that is questionable, since must sulfates are even harsher than SLS. Plus, the inexpensiveness of SLS shampoos and conditioners just make them attractive to beauty monopolies. Did you really expect to get quality ingredients for that $3.00 shampoo? Yes, you make have hair that looks or feels quality, but remember looks can be deceiving.
The Final Word
As more companies respond to the natural and organic personal care movement, the battle between natural ingredients and chemical ingredients will continue to rage on. Your best bet is to find a product that, even if all natural, contains quality ingredients, not simply extracts and ingredients that sound good. By far, some of the highest quality hair care products that I discovered are Beauty 4 Ashes GodHead products, especially their Silky Smooth System. Priced similar to Philosophy and Nexxus, their products actually contain hair healthy natural oils and essential oils and have no sulfates or silicones. Yet, they also produce quality, visible results. You can learn more about their product ingredients at wwwdiscoverb4acom.
About the Author
Kim is a natural lover of hair and for all of her life has enjoyed making others happy through the magic of her hands. She plats, braids, twist, and twirls the hair into amazing creations. She has won numerous awards for her designs and now spends her time on lecturing on how to grow healthy hair.
